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As of now, the FDA has not authorized any products in flavors other than tobacco or menthol, nor has it approved any open-system (refillable) products or bottled e-liquids

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Liver Although the 2004 Surgeon Generals Report concludes that the relationship between smoking and liver cancer is suggestive but not causal, a meta-analysis from the World Health Organization (WHO) International Agency for Research on Cancer found an RR of 1.55 among current smokers and 1.2 among former smokers for development of liver cancer (Lee et al., 2009)